abstract：BACKGROUND:Clinical outcomes and the effects of oral anticoagulants among patients with acute coronary syndrome (ACS) and either a history of or acute heart failure (HF) are largely unknown. We aimed to assess the relationship between prior HF or acute HF complicating an index ACS event and subsequent clinical outcomes...

journal_title：American heart journal

authors： Cornel JH,Lopes RD,James S,Stevens SR,Neely ML,Liaw D,Miller J,Mohan P,Amerena J,Raev D,Huo Y,Urina-Triana M,Gallegos Cazorla A,Vinereanu D,Fridrich V,Harrington RA,Wallentin L,Alexander JH,APPRAISE-2 Study Group.

更新日期：2015-04-01 00:00:00

abstract：:The novel oral anticoagulants (NOACs) have rapidly emerged as an alternative therapy to warfarin. Several recent phase 3 randomized control trials have demonstrated the efficacy and safety of the NOACs in the treatment for patients with nonvalvular atrial fibrillation. As the NOACs are incorporated in clinical practic...

journal_title：American heart journal

authors： Krishnamoorthy A,Sherwood MW,Lopes RD,Becker RC

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Stroke in patients with heart failure is associated with poor outcomes. Risk stratification schemes may improve clinical decision making in this patient population. This study investigated whether female sex is a risk factor for stroke in patients with heart failure in sinus rhythm. METHODS:This is a popula...

journal_title：American heart journal

authors： Melgaard L,Gorst-Rasmussen A,Lip GY,Rasmussen LH,Larsen TB

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Left atrial appendage flow velocity (LAAFV) is a predictor of thromboembolism in atrial fibrillation (AF) patients, as well as CHA2DS2-VASc score. However, little is known about LAAFV in sinus rhythm (SR) after catheter ablation. The aim of this study was to determine clinical predictors of low LAAFV in pati...

journal_title：American heart journal

authors： Kusa S,Komatsu Y,Taniguchi H,Uchiyama T,Takagi T,Nakamura H,Miyazaki S,Hachiya H,Iesaka Y

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Pregnancy is increasingly common in women with congenital heart disease (CHD), but little is known about long-term cardiovascular outcome after pregnancy in these patients. We studied the incidence of cardiovascular events 1-year postpartum and compared cardiac function prepregnancy and 1-year postpartum in ...

journal_title：American heart journal

authors： Kampman MA,Balci A,Groen H,van Dijk AP,Roos-Hesselink JW,van Melle JP,Sollie-Szarynska KM,Wajon EM,Mulder BJ,van Veldhuisen DJ,Pieper PG,ZAHARA II investigators.

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Only limited data from large randomized clinical trials have been published on the long-term performance of second-generation drug-eluting stents in bifurcation lesions. METHODS:We investigated in patients in the randomized TWENTE trial the long-term safety and efficacy of treating bifurcation lesions with ...

journal_title：American heart journal

authors： Lam MK,Sen H,van Houwelingen KG,Löwik MM,van der Heijden LC,Kok MM,de Man FH,Linssen GC,Tandjung K,Doggen CJ,von Birgelen C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Drug-eluting stents (DES) have largely replaced bare-metal stents (BMS) for percutaneous coronary intervention (PCI). It is uncertain, however, whether introduction of DES had a significant impact on the comparative effectiveness of PCI versus coronary artery bypass graft surgery (CABG) for death and myocard...

journal_title：American heart journal

authors： Hlatky MA,Boothroyd DB,Baker LC,Go AS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Protease-activated receptor 1 antagonism with vorapaxar represents a novel strategy for platelet inhibition. In TRACER, vorapaxar was compared with placebo plus standard of care among 12,944 patients with non-ST-segment elevation acute coronary syndromes. We anticipated that most patients would have received...

journal_title：American heart journal

authors： Tricoci P,Lokhnygina Y,Huang Z,Van de Werf F,Cornel JH,Chen E,Wallentin L,Held C,Aylward PE,Moliterno DJ,Jennings LK,White HD,Armstrong PW,Harrington RA,Strony J,Mahaffey KW

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Health care utilization patterns and associated costs of congenital heart disease (CHD) in young adulthood are not well understood. METHODS:California State Inpatient Databases 2005 to 2009 were used to conduct a retrospective study on inpatient admissions of CHD patients 10 to 29 years old (n = 7,419) and ...

journal_title：American heart journal

authors： Lu Y,Agrawal G,Lin CW,Williams RG

更新日期：2014-12-01 00:00:00

abstract：:Fingolimod, a sphingosine-1-phosphate receptor (S1PR) modulator, was the first oral disease-modifying therapy approved for relapsing forms of multiple sclerosis; it reduces autoreactive lymphocytes' egress from lymphoid tissues by down-regulating S1PRs. Sphingosine-1-phosphate signaling is implicated in a range of phy...

journal_title：American heart journal

authors： Camm J,Hla T,Bakshi R,Brinkmann V

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The few available studies of the Centers for Medicare and Medicaid Services Hospital Inpatient Quality Reporting (IQR) care process indicators have not linked receipt of recommended care processes in heart failure (HF) with lower mortality. Because the Veterans Health Administration (VHA) also tracks hospita...

journal_title：American heart journal

authors： Wu WC,Jiang L,Friedmann PD,Trivedi A

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Transcatheter aortic valve replacement (TAVR) is an effective therapeutic option for patients with severe aortic stenosis at high risk for surgery. Identification of causes of death after TAVR may help improve patient selection and outcome. METHODS:We enrolled 874 consecutive patients who underwent TAVR at ...

journal_title：American heart journal

authors： Saia F,Latib A,Ciuca C,Gasparetto V,Napodano M,Sticchi A,Anderlucci L,Marrozzini C,Naganuma T,Alfieri O,Facchin M,Hoxha B,Moretti C,Marzocchi A,Colombo A,Tarantini G

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:In the setting of ST-segment elevation myocardial infarction, timely restoration of normal blood flow is associated with improved myocardial salvage and survival. Despite improvements in door-to-needle and door-to-balloon times, there remains an unmet need with respect to improved symptom-to-door times. A pr...

journal_title：American heart journal

authors： Gibson CM,Krucoff M,Kirtane AJ,Rao SV,Mackall JA,Matthews R,Saba S,Waksman R,Holmes D

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Peak creatine kinase (CK)-MB concentration is related to reperfusion success and clinical outcomes after fibrinolytic therapy for acute myocardial infarction. However, prognostic implications of CK-MB measurements after primary percutaneous coronary intervention (PCI), which provides more predictable and con...

journal_title：American heart journal

authors： Bagai A,Schulte PJ,Granger CB,Mahaffey KW,Christenson RH,Bell G,Lopes RD,Green CL,Lincoff AM,Armstrong PW,Roe MT

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:In the TRACER trial, vorapaxar, a protease-activated receptor-1 antagonist, plus standard care in non-ST-segment elevation acute coronary syndrome (NSTE ACS) patients did not significantly reduce the primary composite end point but reduced a key secondary end point and significantly increased bleeding. Histo...

journal_title：American heart journal

authors： Jones WS,Tricoci P,Huang Z,Moliterno DJ,Harrington RA,Sinnaeve PR,Strony J,Van de Werf F,White HD,Held C,Armstrong PW,Aylward PE,Chen E,Patel MR,Mahaffey KW

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:According to a recent meta-analysis, parathyroid hormone (PTH) excess is associated with increased cardiovascular disease (CVD) risk, but existing studies are limited. We examined in a prospective study the association of PTH with the incidence of CVD, taking into account vitamin D and other confounding vari...

journal_title：American heart journal

authors： Folsom AR,Alonso A,Misialek JR,Michos ED,Selvin E,Eckfeldt JH,Coresh J,Pankow JS,Lutsey PL

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:A simple approach is the predominant strategy for the percutaneous coronary intervention of bifurcation lesions. Performing side branch (SB) predilation in this context is currently a matter of controversy. In this study, we assess the efficacy of SB predilatation before a provisional T-stent strategy for bi...

journal_title：American heart journal

authors： Pan M,Medina A,Romero M,Ojeda S,Martin P,Suarez de Lezo J,Segura J,Mazuelos F,Novoa J,Suarez de Lezo J

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) is evaluating the potential benefit for reduction in major cardiovascular (CV) events from the addition of ezetimibe versus placebo to 40 mg/d of simvastatin therapy in patients who present with acute coronary syndromes and...

journal_title：American heart journal

authors： Blazing MA,Giugliano RP,Cannon CP,Musliner TA,Tershakovec AM,White JA,Reist C,McCagg A,Braunwald E,Califf RM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Prescribing rate control medications with or without antiarrhythmic drugs is often the first course treatment for atrial fibrillation (AF). Clinical trial data suggest that antiarrhythmic drugs are only marginally effective and have multiple drawbacks, whereas rate control alone is sufficient for most patien...

journal_title：American heart journal

authors： Vaughan-Sarrazin MS,Mazur A,Chrischilles E,Cram P

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy with aspirin and clopidogrel is currently recommended in off-pump coronary artery bypass (OPCAB). However, no data exist concerning platelet reactivity on clopidogrel after OPCAB. The aim of this study was to assess the relationship between platelet reactivity and late major adverse...

journal_title：American heart journal

authors： Youn YN,Yi G,Lee S,Joo HC,Yoo KJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Little is known on the "very" long-term incidence of major adverse cardiac events (MACE), target-lesion revascularization (TLR), target-vessel revascularization and stent thrombosis after sirolimus-eluting stent (SES) implantation. We present the first study to provide a 10-year clinical follow-up in an unse...

journal_title：American heart journal

authors： Palhais N,Arroyo D,Lehmann S,Togni M,Kaufmann U,Puricel SG,Stauffer JC,Goy JJ,Cook S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Over 3 million patients annually present with symptoms suggestive of obstructive coronary artery disease (oCAD) in the United States (US), but a cardiac etiology is found in as few as 10% of cases. Usual care may include advanced cardiac testing with myocardial perfusion imaging (MPI), with attendant radiati...

journal_title：American heart journal

authors： Phelps CE,O'Sullivan AK,Ladapo JA,Weinstein MC,Leahy K,Douglas PS

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:P2Y12 receptor antagonist therapy is recommended in addition to ASA for up to 1 year after acute coronary syndrome to reduce ischemic events. In contrast, the benefit of long-term dual antiplatelet therapy beyond 1 year remains unclear. Ticagrelor is a potent, reversibly binding P2Y12 receptor-antagonist tha...

journal_title：American heart journal

authors： Bonaca MP,Bhatt DL,Braunwald E,Cohen M,Steg PG,Storey RF,Held P,Jensen EC,Sabatine MS

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Despite known associations between obesity and cardiovascular disease, the relationship between obesity as reflected by body mass index (BMI) and angiographic coronary artery disease (CAD) is not fully understood. Moreover, this relationship has not been adequately defined in black patients, a group demons...

journal_title：American heart journal

authors： Stalls CM,Triplette MA,Viera AJ,Pathman DE,Cohen MG,Rossi JS

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. METHODS:Among ...

journal_title：American heart journal

authors： Lee SH,Kang DR,Uhm JS,Shim J,Sung JH,Kim JY,Pak HN,Lee MH,Joung B

更新日期：2014-04-01 00:00:00

abstract：:Coronary artery disease remains the leading cause of death in developed countries despite significant progress in primary prevention and treatment strategies. Older patients are at particularly high risk of poor outcomes following acute coronary syndrome and impaired nutrition, including low vitamin D levels, may play...

journal_title：American heart journal

authors： Kunadian V,Ford GA,Bawamia B,Qiu W,Manson JE

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Patients with non-ST-elevation myocardial infarction (NSTEMI) and three-vessel or left main coronary disease (3VD/LMD) have a high risk of long-term mortality when treated with a medical management strategy (MMS) compared with revascularization. METHODS:We evaluated patterns of use and patient features acro...

journal_title：American heart journal

authors： Harskamp RE,Wang TY,Bhatt DL,Wiviott SD,Amsterdam EA,Li S,Thomas L,de Winter RJ,Roe MT

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Exercise training is recommended for chronic heart failure (HF) patients to improve functional status and reduce risk of adverse outcomes. Elevated plasma levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), and cardiac troponin T (cTnT) are associ...

journal_title：American heart journal

authors： Ahmad T,Fiuzat M,Mark DB,Neely B,Neely M,Kraus WE,Kitzman DW,Whellan DJ,Donahue M,Zannad F,Piña IL,Adams K,O'Connor CM,Felker GM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The human KCNE1 protein forms the β-subunit of the IKs potassium channel and is important in the regulation of the atrial action potential duration. The purpose of this study was to investigate the association between the nonsynonymous 112G>A mutation of the KCNE1 gene and postcardiac surgery atrial fibrilla...

journal_title：American heart journal

authors： Voudris KV,Apostolakis S,Karyofillis P,Doukas K,Zaravinos A,Androutsopoulos VP,Michalis A,Voudris V,Spandidos DA

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to assess trends in evidence-based therapy use and short- and long-term mortality over time among older patients with non-ST-segment elevation myocardial infarction (NSTEMI). BACKGROUND:With the prevalence of national quality improvement efforts, the use of evidence-based ther...

journal_title：American heart journal

authors： Chin CT,Wang TY,Chen AY,Mathews R,Alexander KP,Roe MT,Peterson ED

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:African-American ancestry, hypokalemia, and QT interval prolongation on the electrocardiogram are all risk factors for sudden cardiac death (SCD), but their interactions remain to be characterized. SCN5A-1103Y is a common missense variant, of African ancestry, of the cardiac sodium channel gene. SCN5A-1103Y ...

journal_title：American heart journal

authors： Akylbekova EL,Payne JP,Newton-Cheh C,May WL,Fox ER,Wilson JG,Sarpong DF,Taylor HA,Maher JF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Although high-sensitivity cardiac troponin (hs-cTn) substantially improves the early detection of myocardial injury, it lacks specificity for acute myocardial infarction (MI). In suspected non-ST-elevation MI, invasive coronary angiography (ICA) remains necessary to distinguish between acute MI and noncorona...

journal_title：American heart journal

authors： Smulders MW,Kietselaer BL,Das M,Wildberger JE,Crijns HJ,Veenstra LF,Brunner-La Rocca HP,van Dieijen-Visser MP,Mingels AM,Dagnelie PC,Post MJ,Gorgels AP,van Asselt AD,Vogel G,Schalla S,Kim RJ,Bekkers SC

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:In the United States as well as globally, Asians are a growing proportion of patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI), yet little is known about their longitudinal outcomes. METHODS:We linked Centers for Medicare & Medicaid claims data to detailed clinical data for 37...

journal_title：American heart journal

authors： Xu W,Holmes DN,Becker RC,Roe MT,Peterson ED,Wang TY

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The objective was to report recent trends in the incidence, adoption of evidence-based treatment, and clinical outcomes for first-time hospitalization for acute myocardial infarction. METHODS:This is a large retrospective population-based cohort study using medical administrative data (International Classif...

journal_title：American heart journal

authors： Ortolani P,Marino M,Melandri G,Guastaroba P,Corzani A,Berti E,Rapezzi C,De Palma R,Branzi A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Guidelines recommend consideration of cardiac biomarker measurement after elective percutaneous coronary intervention (PCI), especially with complex cases or complicated procedures. However, the long-term prognostic implications of biomarker measurement after elective PCI have not been well characterized in ...

journal_title：American heart journal

authors： Wang TY,McCoy LA,Messenger JC,Neely ML,Ho KK,Roe MT,Anderson HV

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Rheumatic disease and heart disease share common underpinnings involving inflammation. The high levels of inflammation that characterize rheumatic diseases provide a "natural experiment" to help elucidate the mechanisms by which inflammation accelerates heart disease. Rheumatoid arthritis (RA) is the most co...

journal_title：American heart journal

authors： Crowson CS,Liao KP,Davis JM 3rd,Solomon DH,Matteson EL,Knutson KL,Hlatky MA,Gabriel SE

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Over the past decade, electronic health records (EHRs) have emerged as a potential tool to assess quality of care; however, the feasibility and accuracy of EHRs to assess adherence to lipid management performance measures have not been evaluated. METHODS:We created a retrospective cohort of 3779 patients wi...

journal_title：American heart journal

authors： Danford CP,Navar-Boggan AM,Stafford J,McCarver C,Peterson ED,Wang TY

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HC) is the most prevalent genetic cardiac disease caused by a mutation in sarcomeres, Z-disks, or calcium-handling genes and is characterized by unexplained left ventricular hypertrophy. The aim of this study was to determine the genetic profile of Brazilian patients with HC and ...

journal_title：American heart journal

authors： Marsiglia JD,Credidio FL,de Oliveira TG,Reis RF,Antunes Mde O,de Araujo AQ,Pedrosa RP,Barbosa-Ferreira JM,Mady C,Krieger JE,Arteaga-Fernandez E,Pereira Ada C

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptors (PPARs) regulate transcription of genes involved in glucose uptake, lipid metabolism, and inflammation. Aleglitazar is a potent dual PPAR agonist with insulin-sensitizing and glucose-lowering actions and favorable effects on lipid profiles and biomarkers of cardiov...

journal_title：American heart journal

authors： Lincoff AM,Tardif JC,Neal B,Nicholls SJ,Rydén L,Schwartz GG,Malmberg K,Buse JB,Henry RR,Wedel H,Weichert A,Cannata R,Grobbee DE

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is histopathologically characterized by myocyte hypertrophy, disarray, interstitial fibrosis, and small intramural coronary arteriole dysplasia, which contribute to disease progression. Longitudinal systolic and early diastolic strain rate (SR) measurements by speckle tracki...

journal_title：American heart journal

authors： Kobayashi T,Popovic Z,Bhonsale A,Smedira NG,Tan C,Rodriguez ER,Thamilarasan M,Lytle BW,Lever HM,Desai MY

更新日期：2013-09-01 00:00:00